hemoglobin-oxygen dissociation curve
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biology 2: physiology
summary
the hemoglobin-oxygen dissociation curve and the bohr effect are crucial concepts for understanding how oxygen is transported and released to tissues in the body, which are heavily tested on the mcat.
- hemoglobin's affinity for oxygen varies along the sigmoidal-shaped dissociation curve, influenced by cooperativity.
- physiological conditions can shift the curve right (indicating decreased oxygen affinity) or left (indicating increased oxygen affinity), affecting oxygen release or uptake.
- right shift conditions include increased temperature, pco2, hydrogen ion concentration (decreased ph), and levels of 2,3-bisphosphoglycerate, often occurring during exercise.
- left shift conditions are the opposite, including decreased temperature, pco2, hydrogen ion concentration, and 2,3-bpg levels, beneficial in scenarios like fetal oxygen uptake.
- the bohr effect explains how increased co2 levels (and thus decreased ph) in the blood lead to a right shift in the curve, facilitating oxygen unloading to tissues.
chapters
00:01
introduction to hemoglobin-oxygen dissociation curve
00:42
physiological influences on oxygen transport
01:33
right and left shifts of the dissociation curve
06:50
the bohr effect and its implications